FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term methylosome ID (Ontology) GO:0034709 (Gene Ontology)
Definition A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.[ PubMed:11713266 PubMed:11756452 ]
Also Known As"20S methylosome" ; "20S methyltransferase complex"
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Genes (FBgn)GO_CELLULAR_COMPONENT
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 methylosome (all annotations which use CV term, excluding "NOT" statements)
     part_of | methylosome
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intracellular anatomical structure
 |__cytoplasm__________________
 |__methyltransferase complex__|
cellular anatomical structure  |
 |__cytoplasm__________________|
transferase complex            |
 |__methyltransferase complex__|
                               methylosome  1 rec.
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Is a methyltransferase complex
Part of cytoplasm
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Synonyms
  • "20S methylosome" EXACT
    "20S methyltransferase complex" EXACT
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