FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term NAD-dependent protein lysine deacetylase activity ID (Ontology) GO:0034979 (Gene Ontology)
Definition Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a protein to NAD, producing nicotinamide.
Also Known As"NAD(+)-dependent protein deacetylase"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 NAD-dependent protein lysine deacetylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | NAD-dependent protein lysine deacetylase activity
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acyltransferase activity, transferring groups other than amino-acyl groups__
catalytic activity, acting on a protein_____________________________________|
deacylase activity__________________________________________________________|
                                                                            NAD-dependent protein lysine deacylase activity
                                                                             |__NAD-dependent protein lysine deacetylase activity  6 rec.
                                                                                 |__histone deacetylase activity, NAD-dependent 6 rec.
                                                                                 |   |__histone H3K4 deacetylase activity, NAD-dependent
                                                                                 |   |__histone H3K9 deacetylase activity, NAD-dependent 2 rec.
                                                                                 |   |__histone H3K14 deacetylase activity, NAD-dependent 1 rec.
                                                                                 |   |__histone H3K18 deacetylase activity, NAD-dependent 1 rec.
                                                                                 |   |__histone H3K56 deacetylase activity, NAD-dependent
                                                                                 |   |__histone H4K16 deacetylase activity, NAD-dependent 1 rec.
                                                                                 |__NAD-dependent protein lysine delactylase activity
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Synonyms
  • "NAD(+)-dependent protein deacetylase" EXACT
    "NAD(+)-dependent protein deacylase" BROAD
    "NAD-dependent protein deacetylase activity" BROAD
    "protein acetyllysine N-acetyltransferase" BROAD
    "protein lysine deacetylase" BROAD
    "protein lysine deacylase" BROAD
Secondary IDs
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EC:2.3.1.286
Reactome:R-HSA-3371467 "SIRT1 deacetylates HSF1"
Reactome:R-HSA-5211239 "SIRT1 deacetylates TAF1B in SL1 complex"
Reactome:R-HSA-5685953 "SIRT6 deacetylates RBBP8"
Reactome:R-HSA-5688289 "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2"
Reactome:R-HSA-5688294 "SIRT5 deacetylates Cytochrome C"
Reactome:R-HSA-9620532 "SIRT1,SIRT3 deacetylate FOXO3"
Reactome:R-HSA-9667952 "ANKLE2 is deacetylated by SIRT2"
Reactome:R-HSA-9854463 "SIRT3 deacetylates AcK-IDH2 dimer"
RHEA:43636