FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term 1-phosphatidylinositol-4-phosphate 3-kinase activity ID (Ontology) GO:0035005 (Gene Ontology)
Definition Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + H+.[ EC:2 ]
Also Known As "phosphatidylinositol-4-phosphate 3-kinase activity"
Comment
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 1-phosphatidylinositol-4-phosphate 3-kinase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | 1-phosphatidylinositol-4-phosphate 3-kinase activity       2
 NOT | enables | 1-phosphatidylinositol-4-phosphate 3-kinase activity       1
Spanning Tree (Parents/Children)
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lipid kinase activity___________________________________
phosphotransferase activity, alcohol group as acceptor__|
                                                        phosphatidylinositol kinase activity
                                                         |__1-phosphatidylinositol-4-phosphate 3-kinase activity  2 rec.
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Is a phosphatidylinositol kinase activity
Part of
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Synonyms
  • "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity" RELATED[ EC:2 ]
    "C2-domain-containing phosphoinositide 3-kinase activity" NARROW[ EC:2 ]
    "phosphatidylinositol 3-kinase activity, class I" NARROW
    "phosphatidylinositol 3-kinase activity, class II" NARROW
    "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW
    "phosphatidylinositol-4-phosphate 3-kinase activity" EXACT
    "type II phosphoinositide 3-kinase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.1.154
KEGG_REACTION:R05795
MetaCyc:2.7.1.154-RXN
Reactome:R-HSA-1675928 "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane"
Reactome:R-HSA-1676109 "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane"
Reactome:R-HSA-1676206 "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane"
Reactome:R-HSA-8868072 "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2"
RHEA:18373