FB2026_03 , released September 17, 2026
CV Term Report
Help Close All Open All
General Information
Term miRNA-mediated post-transcriptional gene silencing ID (Ontology) GO:0035195 (Gene Ontology)
Definition A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants.[ PubMed:14744438 PubMed:15066275 PubMed:15066283 PubMed:23209154 PubMed:23985560 PubMed:28379604 ]
Also Known As"gene silencing by microRNA" ; "gene silencing by miRNA" ; "microRNA-mediated gene silencing"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

    • Results list data from multiple species. Choose a record type above to open its HitList.
Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 miRNA-mediated post-transcriptional gene silencing (all annotations which use CV term, excluding "NOT" statements)
     involved_in | miRNA-mediated post-transcriptional gene silencing       --
Spanning Tree (Parents/Children)
Only view relationship:
Vocabulary search 
post-transcriptional gene silencing_______
regulatory ncRNA-mediated gene silencing__|
                                          regulatory ncRNA-mediated post-transcriptional gene silencing
                                           |__miRNA-mediated post-transcriptional gene silencing  162 rec.
                                               |__miRNA-mediated gene silencing by inhibition of translation 18 rec.
                                               |__miRNA-mediated gene silencing by mRNA destabilization 24 rec.
                                               |__pre-miRNA export from nucleus
                                               |__regulation of miRNA-mediated gene silencing 12 rec.
                                                   |__negative regulation of miRNA-mediated gene silencing(+) 9 rec.
                                                   |__positive regulation of miRNA-mediated gene silencing(+) 2 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a regulatory ncRNA-mediated post-transcriptional gene silencing
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "gene silencing by microRNA" EXACT
    "gene silencing by miRNA" EXACT
    "microRNA-mediated gene silencing" EXACT
    "miRNA-mediated gene silencing" BROAD
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-9759811 "Regulation of CDH11 mRNA translation by microRNAs"