FB2026_03 , released September 17, 2026
CV Term Report
Help Close All Open All
General Information
Term protein-arginine omega-N symmetric methyltransferase activity ID (Ontology) GO:0035243 (Gene Ontology)
Definition Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues.[ EC:2 PubMed:14705965 ]
Also Known As"protein arginine omega-N symmetric methylase activity" ; "protein arginine omega-N symmetric methyltransferase activity"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

    • Results list data from multiple species. Choose a record type above to open its HitList.
Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 protein-arginine omega-N symmetric methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | protein-arginine omega-N symmetric methyltransferase activity
Spanning Tree (Parents/Children)
Only view relationship:
Vocabulary search 
protein methyltransferase activity_____
arginine N-methyltransferase activity__|
                                       protein-arginine N-methyltransferase activity
                                        |__protein-arginine omega-N symmetric methyltransferase activity  3 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a protein-arginine N-methyltransferase activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "protein arginine omega-N symmetric methylase activity" EXACT
    "protein arginine omega-N symmetric methyltransferase activity" EXACT
    "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming)" RELATED[ EC:2 ]
    "type II PRMT activity" RELATED
    "type II protein arginine methyltransferase activity" RELATED
Secondary IDs
hide External Crossreferences & Linkouts
EC:2.1.1.320
Reactome:R-HSA-6804383 "PRMT5 methylates TP53"
RESID:AA0067
RESID:AA0069
RHEA:48108