FB2026_03 , released September 17, 2026
CV Term Report
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Term Notch receptor processing, ligand-dependent ID (Ontology) GO:0035333 (Gene Ontology)
Definition The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD).[ PubMed:12651094 ]
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 Notch receptor processing, ligand-dependent (all annotations which use CV term, excluding "NOT" statements)
     involved_in | Notch receptor processing, ligand-dependent
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cell surface receptor signaling pathway
 |__Notch signaling pathway____________________________
protein metabolic process                              |
 |__Notch receptor processing__________________________|
membrane protein proteolysis                           |
 |__membrane protein intracellular domain proteolysis__|
                                                       Notch receptor processing, ligand-dependent  4 rec.
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Is a membrane protein intracellular domain proteolysis
Part of Notch signaling pathway
Notch receptor processing
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