FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term oxidative RNA demethylase activity ID (Ontology) GO:0035515 (Gene Ontology)
Definition Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.[ PubMed:12594517 PubMed:16482161 PubMed:18775698 ]
Also Known As "2-oxoglutarate-dependent RNA demethylase"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 oxidative RNA demethylase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | oxidative RNA demethylase activity       1
Spanning Tree (Parents/Children)
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catalytic activity
 |__demethylase activity_______________________________________________________________________________
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  |
 |__2-oxoglutarate-dependent dioxygenase activity______________________________________________________|
dioxygenase activity                                                                                   |
 |__2-oxoglutarate-dependent dioxygenase activity______________________________________________________|
catalytic activity, acting on a nucleic acid                                                           |
 |__catalytic activity, acting on RNA__________________________________________________________________|
                                                                                         oxidative RNA demethylase activity  1 rec.
                                                                                          |__mRNA N1-methyladenosine dioxygenase activity
                                                                                          |__mRNA N6-methyladenosine dioxygenase activity
                                                                                          |__tRNA demethylase activity
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Is a 2-oxoglutarate-dependent dioxygenase activity
demethylase activity
catalytic activity, acting on RNA
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Reactome:R-HSA-8857692 "RNA demethylases demethylate N6-methyladenosine RNA"