FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term broad specificity oxidative DNA demethylase activity ID (Ontology) GO:0035516 (Gene Ontology)
Definition Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA.[ PubMed:12594517 PubMed:16482161 PubMed:18775698 PubMed:19786499 ]
Also Known As "2-oxoglutarate-dependent DNA demethylase"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 broad specificity oxidative DNA demethylase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | broad specificity oxidative DNA demethylase activity       1
Spanning Tree (Parents/Children)
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oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
 |__2-oxoglutarate-dependent dioxygenase activity__
demethylase activity                               |
 |__DNA demethylase activity_______________________|
dioxygenase activity                               |
 |__2-oxoglutarate-dependent dioxygenase activity__|
catalytic activity, acting on DNA                  |
 |__DNA demethylase activity_______________________|
                                                   broad specificity oxidative DNA demethylase activity  1 rec.
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Is a 2-oxoglutarate-dependent dioxygenase activity
DNA demethylase activity
Part of
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Synonyms
  • "1-ethyladenine demethylase activity" NARROW
    "2-oxoglutarate-dependent DNA demethylase" EXACT[ PubMed:17991826 ]
    "5-formylcytosine dioxygenase activity" NARROW
    "5-hydroxymethylcytosine dioxygenase activity" NARROW
    "5fC dioxygenase" NARROW
    "5hmC dioxygenase" NARROW
    "N1-methyladenine demethylase activity" NARROW
    "N3-methylcytosine demethylase activity" NARROW
    "oxidative DNA demethylase activity" BROAD
Secondary IDs
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EC:1.14.11.33
MetaCyc:RXN-12353
Reactome:R-HSA-112118 "Oxidative demethylation of 1-meA damaged DNA by ALKBH2"
Reactome:R-HSA-112123 "Oxidative demethylation of 1-meA damaged DNA By ALKBH3"
RHEA:30299
RHEA:70435
RHEA:70439
RHEA:70443
RHEA:70447