FB2026_03 , released September 17, 2026
CV Term Report
Help Close All Open All
General Information
Term broad specificity oxidative DNA demethylase activity ID (Ontology) GO:0035516 (Gene Ontology)
Definition Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA.[ PubMed:12594517 PubMed:16482161 PubMed:18775698 PubMed:19786499 ]
Also Known As"2-oxoglutarate-dependent DNA demethylase"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

    • Results list data from multiple species. Choose a record type above to open its HitList.
Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 broad specificity oxidative DNA demethylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | broad specificity oxidative DNA demethylase activity
Spanning Tree (Parents/Children)
Only view relationship:
Vocabulary search 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
 |__2-oxoglutarate-dependent dioxygenase activity__
demethylase activity                               |
 |__DNA demethylase activity_______________________|
dioxygenase activity                               |
 |__2-oxoglutarate-dependent dioxygenase activity__|
catalytic activity, acting on DNA                  |
 |__DNA demethylase activity_______________________|
                                                   broad specificity oxidative DNA demethylase activity  1 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a 2-oxoglutarate-dependent dioxygenase activity
DNA demethylase activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "1-ethyladenine demethylase activity" NARROW
    "2-oxoglutarate-dependent DNA demethylase" EXACT[ PubMed:17991826 ]
    "5-formylcytosine dioxygenase activity" NARROW
    "5-hydroxymethylcytosine dioxygenase activity" NARROW
    "5fC dioxygenase" NARROW
    "5hmC dioxygenase" NARROW
    "N1-methyladenine demethylase activity" NARROW
    "N3-methylcytosine demethylase activity" NARROW
    "oxidative DNA demethylase activity" BROAD
Secondary IDs
hide External Crossreferences & Linkouts
EC:1.14.11.33
MetaCyc:RXN-12353
Reactome:R-HSA-112118 "Oxidative demethylation of 1-meA damaged DNA by ALKBH2"
Reactome:R-HSA-112123 "Oxidative demethylation of 1-meA damaged DNA By ALKBH3"
RHEA:30299
RHEA:70435
RHEA:70439
RHEA:70443
RHEA:70447