FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
Help Close All Open All
General Information
Term histone H4K20 demethylase activity ID (Ontology) GO:0035575 (Gene Ontology)
Definition Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.[ PubMed:20622853 PubMed:26214369 PubMed:32209475 ]
Also Known As "histone demethylase activity (H4-K20 specific)" ; "histone demethylase activity (H4K20-specific)" ; "histone H4-K20 demethylase activity" (for all, see Synonyms field below)
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

    • Results list data from multiple species. Choose a record type above to open its HitList.
Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 histone H4K20 demethylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | histone H4K20 demethylase activity
Spanning Tree (Parents/Children)
Only view relationship:
Vocabulary search 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
 |__2-oxoglutarate-dependent dioxygenase activity__
histone demethylase activity                       |
 |__histone H4 demethylase activity________________|
dioxygenase activity                               |
 |__2-oxoglutarate-dependent dioxygenase activity__|
                                                   histone H4K20 demethylase activity  1 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a 2-oxoglutarate-dependent dioxygenase activity
histone H4 demethylase activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "histone demethylase activity (H4-K20 specific)" EXACT
    "histone demethylase activity (H4K20-specific)" EXACT
    "histone H4-K20 demethylase activity" EXACT
    "histone H4-methyl-lysine-20 demethylase activity" EXACT
    "histone H4K20me demethylase activity" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-2172678 "PHF8 demethylates histone H4K20me1"
RHEA:67804
RHEA:85907
RHEA:85911