FB2026_03 , released September 17, 2026
CV Term Report
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Term tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity ID (Ontology) GO:0035598 (Gene Ontology)
Definition Catalysis of the reaction: N(6)-L-threonylcarbamoyladenosine(37) in tRNA + [sulfur carrier]-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + [sulfur carrier]-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H+.[ PubMed:20472640 PubMed:20584901 ]
Also Known As"N6-threonylcarbomyladenosine methylthiotransferase activity" ; "t6A methylthiotransferase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity
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alkylthioltransferase activity
 |__methylthiotransferase activity________
catalytic activity, acting on RNA         |
 |__catalytic activity, acting on a tRNA__|
                                          tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity  1 rec.
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Is a methylthiotransferase activity
catalytic activity, acting on a tRNA
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Synonyms
  • "N6-threonylcarbomyladenosine methylthiotransferase activity" EXACT
    "t6A methylthiotransferase activity" EXACT[ PubMed:20472640 ]
Secondary IDs
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EC:2.8.4.5
MetaCyc:RXN-14531
Reactome:R-HSA-6786571 "CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37"
RHEA:37075