FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term folate cycle ID (Ontology) GO:0035999 (Gene Ontology)
Definition A cyclic series of interconversions of the one-carbon unit carried by tetrahydrofolate - as 10-formyltetrahydrofolate, 5,10-methenyltetrahydrofolate, 5,10-methylenetetrahydrofolate and 5-methyltetrahydrofolate. Couples the acquisition of a one-carbon unit from donors such as serine, glycine or formate with its transfer, in the appropriate oxidation state, to biosynthetic acceptors, and with regeneration of tetrahydrofolate.[ PubMed:1825999 PubMed:18804690 PubMed:27641100 ]
Also Known As"folate transformations" ; "folate-mediated one-carbon metabolism" ; "folic acid cycle" (for all, see Synonyms field below)
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 folate cycle (all annotations which use CV term, excluding "NOT" statements)
     involved_in | folate cycle
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folic acid-containing compound biosynthetic process
 |__tetrahydrofolate biosynthetic process__
small molecule metabolic process           |
 |__one-carbon metabolic process___________|
tetrahydrofolate metabolic process         |
 |__tetrahydrofolate biosynthetic process__|
                                           folate cycle  5 rec.
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Is a one-carbon metabolic process
tetrahydrofolate biosynthetic process
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Synonyms
  • "folate transformations" EXACT
    "folate-mediated one-carbon metabolism" EXACT
    "folic acid cycle" EXACT
    "tetrahydrofolate interconversion" EXACT
Secondary IDs
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MetaCyc:1CMET2-PWY
MetaCyc:PWY-2201
MetaCyc:PWY-3841