FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term prostaglandin H2 endoperoxidase reductase activity ID (Ontology) GO:0036130 (Gene Ontology)
Definition Catalysis of the reaction: prostaglandin F2alpha + NADP+ = prostaglandin H2 + NADPH + H+.[ PubMed:10622721 PubMed:14979715 PubMed:16475787 ]
Also Known As"PGH2 9,11-endoperoxidase" ; "PGH2 9-,11-endoperoxide reductase"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 prostaglandin H2 endoperoxidase reductase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | prostaglandin H2 endoperoxidase reductase activity
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  oxidoreductase activity, acting on CH-OH group of donors
   |__oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
       |__prostaglandin H2 endoperoxidase reductase activity  1 rec.
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Is a oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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KEGG_REACTION:R02264
Reactome:R-HSA-2161549 "PGH2 is reduced to PGF2a by AKR1C3"
RHEA:45312