FB2026_03 , released September 17, 2026
CV Term Report
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Term protein modification process ID (Ontology) GO:0036211 (Gene Ontology)
Definition The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
Also Known As"cellular protein modification process" ; "process resulting in protein modification" ; "protein modification"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 protein modification process (all annotations which use CV term, excluding "NOT" statements)
     involved_in | protein modification process       --
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macromolecule metabolic process
 |__protein metabolic process___
 |__macromolecule modification__|
primary metabolic process       |
 |__protein metabolic process___|
                                protein modification process  489 rec.
                                 |__actin modification 1 rec.
                                 |   |__actin ubiquitination
                                 |__metal incorporation into metallo-molybdopterin complex
                                 |   |__molybdenum incorporation into molybdenum-molybdopterin complex
                                 |   |__tungsten incorporation into tungsten-molybdopterin complex
                                 |__metal incorporation into metallo-sulfur cluster
                                 |   |__copper incorporation into metallo-sulfur cluster(+)
                                 |   |__iron incorporation into metallo-sulfur cluster
                                 |   |__molybdenum incorporation into metallo-sulfur cluster(+)
                                 |   |__nickel incorporation into metallo-sulfur cluster
                                 |__N-terminal protein amino acid modification 12 rec.
                                 |   |__N-terminal peptidyl-alanine trimethylation
                                 |   |__N-terminal peptidyl-proline dimethylation
                                 |   |__N-terminal peptidyl-serine dimethylation
                                 |   |__N-terminal peptidyl-serine trimethylation
                                 |   |__N-terminal protein amino acid acetylation(+) 11 rec.
                                 |   |__N-terminal protein amino acid carbamoylation
                                 |   |__N-terminal protein amino acid carboxylation
                                 |   |__N-terminal protein amino acid deamination(+)
                                 |   |__N-terminal protein amino acid methylation(+)
                                 |   |__N-terminal protein formylation
                                 |   |__N-terminal protein lipidation(+) 1 rec.
                                 |__nucleic acid-protein covalent cross-linking
                                 |   |__RNA-protein covalent cross-linking
                                 |__peptide cross-linking
                                 |   |__isopeptide cross-linking(+)
                                 |   |__peptide cross-linking via L-cystine
                                 |__peptidyl-arginine modification 1 rec.
                                 |   |__peptidyl-arginine hydroxylation
                                 |   |__peptidyl-arginine methylation(+) 1 rec.
                                 |   |__peptidyl-arginine phosphorylation
                                 |__peptidyl-glutamic acid modification 6 rec.
                                 |   |__N-terminal peptidyl-glutamic acid acetylation 1 rec.
                                 |   |__peptidyl-glutamic acid carboxylation
                                 |   |__protein deglutamylation(+)
                                 |   |__protein polyglutamylation 1 rec.
                                 |   |__protein polyglycylation(+) 4 rec.
                                 |__peptidyl-glycine modification
                                 |   |__N-terminal peptidyl-glycine methylation
                                 |   |__N-terminal peptidyl-glycine N-myristoylation
                                 |__peptidyl-lysine modification 31 rec.
                                 |   |__isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
                                 |   |__peptidyl-lysine acetylation(+) 1 rec.
                                 |   |__peptidyl-lysine deacetylation
                                 |   |__peptidyl-lysine deglycation
                                 |   |__peptidyl-lysine demalonylation
                                 |   |__peptidyl-lysine desuccinylation
                                 |   |__peptidyl-lysine hydroxylation(+) 1 rec.
                                 |   |__peptidyl-lysine methylation(+) 4 rec.
                                 |   |__peptidyl-lysine oxidation
                                 |   |__protein desumoylation(+) 6 rec.
                                 |   |__protein lipoylation 2 rec.
                                 |   |__protein pupylation
                                 |   |__protein sumoylation(+) 17 rec.
                                 |   |__protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
                                 |__peptidyl-methionine modification 2 rec.
                                 |   |__N-terminal peptidyl-methionine acetylation(+) 1 rec.
                                 |__peptidyl-phenylalanine modification
                                 |__peptidyl-proline modification 5 rec.
                                 |   |__peptidyl-proline hydroxylation(+)
                                 |   |__protein peptidyl-prolyl isomerization 5 rec.
                                 |__post-translational protein modification 355 rec.
                                 |   |__C-terminal protein amino acid modification(+)
                                 |   |__N-terminal protein amino acid propionylation
                                 |   |__post-translational protein acetylation
                                 |   |__protein auto-ADP-ribosylation
                                 |   |__protein modification by small protein conjugation or removal(+) 339 rec.
                                 |   |__protein poly-ADP-ribosylation
                                 |   |__regulation of post-translational protein modification(+) 30 rec.
                                 |__protein acylation 13 rec.
                                 |   |__peptidyl-lysine butyrylation
                                 |   |__peptidyl-lysine crotonylation(+)
                                 |   |__peptidyl-lysine glutarylation
                                 |   |__peptidyl-lysine propionylation
                                 |   |__protein acetylation(+) 12 rec.
                                 |   |__protein decanoylation
                                 |   |__protein formylation(+)
                                 |   |__protein malonylation
                                 |   |__protein myristoylation(+)
                                 |   |__protein octanoylation(+)
                                 |   |__protein palmitoleylation
                                 |   |__protein palmitoylation(+) 1 rec.
                                 |   |__protein succinylation
                                 |__protein alkylation 6 rec.
                                 |   |__protein methylation(+) 6 rec.
                                 |__protein arginylation
                                 |__protein carbamoylation
                                 |__protein carboxylation
                                 |   |__peptidyl-glutamic acid carboxylation
                                 |__protein de-ADP-ribosylation
                                 |   |__peptidyl-glutamate ADP-deribosylation
                                 |   |__peptidyl-serine ADP-deribosylation
                                 |__protein deacylation 1 rec.
                                 |   |__protein deacetylation(+)
                                 |   |__protein deglutarylation
                                 |   |__protein demalonylation(+)
                                 |   |__protein depalmitoleylation 1 rec.
                                 |   |__protein depalmitoylation
                                 |   |__protein depropionylation
                                 |   |__protein desuccinylation(+)
                                 |__protein dealkylation
                                 |   |__protein demethylation(+)
                                 |__protein deamination
                                 |__protein deglutathionylation
                                 |__protein deglycation
                                 |   |__peptidyl-lysine deglycation
                                 |   |__protein deglycation, glyoxal removal
                                 |   |__protein deglycation, methylglyoxal removal
                                 |__protein deglycosylation 3 rec.
                                 |   |__protein deglycosylation involved in glycoprotein catabolic process(+)
                                 |   |__protein demannosylation(+) 2 rec.
                                 |__protein dehydration
                                 |__protein delipidation
                                 |__protein denucleotidylation 1 rec.
                                 |   |__protein deadenylylation 1 rec.
                                 |__protein dephosphorylation 20 rec.
                                 |   |__peptidyl-histidine dephosphorylation
                                 |   |__peptidyl-N-phospho-arginine dephosphorylation 1 rec.
                                 |   |__peptidyl-serine dephosphorylation
                                 |   |__peptidyl-threonine dephosphorylation
                                 |   |__peptidyl-tyrosine dephosphorylation(+)
                                 |   |__regulation of translational initiation by eIF2 alpha dephosphorylation(+)
                                 |__protein flavinylation
                                 |__protein glutathionylation
                                 |   |__regulation of protein glutathionylation(+)
                                 |__protein histidyl modification to diphthamide 8 rec.
                                 |__protein hydroxylation 3 rec.
                                 |   |__peptidyl-aspartic acid hydroxylation
                                 |   |__peptidyl-lysine hydroxylation(+) 1 rec.
                                 |   |__peptidyl-proline hydroxylation(+)
                                 |   |__peptidyl-tyrosine hydroxylation
                                 |__protein lipidation 1 rec.
                                 |   |__C-terminal protein lipidation(+)
                                 |   |__N-terminal protein lipidation(+) 1 rec.
                                 |   |__protein decanoylation
                                 |   |__protein myristoylation(+)
                                 |   |__protein octanoylation(+)
                                 |   |__protein palmitoleylation
                                 |   |__protein palmitoylation(+) 1 rec.
                                 |   |__protein stearoylation
                                 |   |__regulation of protein lipidation(+)
                                 |__protein nitrosylation
                                 |   |__peptidyl-cysteine S-nitrosylation(+)
                                 |__protein nucleotidylation 1 rec.
                                 |   |__protein adenylylation(+) 1 rec.
                                 |   |__protein guanylylation
                                 |   |__protein uridylylation
                                 |__protein oxidation
                                 |   |__peptidyl-cysteine oxidation
                                 |   |__peptidyl-lysine oxidation
                                 |   |__regulation of protein oxidation(+)
                                 |__protein phosphopantetheinylation
                                 |   |__peptidyl-serine phosphopantetheinylation
                                 |__protein phosphorylation 64 rec.
                                 |   |__I-kappaB phosphorylation(+)
                                 |   |__inhibitory G protein-coupled receptor phosphorylation(+)
                                 |   |__JUN phosphorylation
                                 |   |__peptidyl-arginine phosphorylation
                                 |   |__peptidyl-aspartic acid phosphorylation
                                 |   |__peptidyl-histidine phosphorylation
                                 |   |__peptidyl-serine phosphorylation(+) 2 rec.
                                 |   |__peptidyl-threonine phosphorylation(+)
                                 |   |__peptidyl-tyrosine phosphorylation(+)
                                 |   |__protein autophosphorylation(+) 5 rec.
                                 |   |__regulation of protein phosphorylation(+) 12 rec.
                                 |   |__regulation of translational initiation by eIF2 alpha phosphorylation(+)
                                 |__protein polyamination
                                 |__protein prenylation
                                 |   |__protein farnesylation
                                 |   |__protein geranylgeranylation(+)
                                 |__protein sialylation
                                 |__protein sulfation
                                 |   |__peptidyl-tyrosine sulfation
                                 |__protein sulfhydration
                                 |   |__peptidyl-cystine sulfhydration
                                 |__protein-coenzyme A linkage
                                 |   |__protein-phosphoribosyl dephospho-coenzyme A linkage
                                 |__protein-FAD linkage 2 rec.
                                 |__protein-pyridoxal-5-phosphate linkage
                                 |   |__protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
                                 |   |__regulation of protein-pyridoxal-5-phosphate linkage(+)
                                 |__regulation of protein modification process 43 rec.
                                     |__negative regulation of protein modification process(+) 8 rec.
                                     |__positive regulation of protein modification process(+) 26 rec.
                                     |__regulation of peptidyl-cysteine S-nitrosylation(+)
                                     |__regulation of peptidyl-lysine crotonylation(+)
                                     |__regulation of post-translational protein modification(+) 30 rec.
                                     |__regulation of protein acetylation(+)
                                     |__regulation of protein adenylylation(+)
                                     |__regulation of protein deacetylation(+)
                                     |__regulation of protein geranylgeranylation(+)
                                     |__regulation of protein glutathionylation(+)
                                     |__regulation of protein lipidation(+)
                                     |__regulation of protein oxidation(+)
                                     |__regulation of protein phosphorylation(+) 12 rec.
                                     |__regulation of protein polyglycylation(+) 1 rec.
                                     |__regulation of protein-pyridoxal-5-phosphate linkage(+)
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Is a protein metabolic process
macromolecule modification
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Synonyms
  • "cellular protein modification process" EXACT
    "process resulting in protein modification" EXACT
    "protein modification" EXACT
Secondary IDs
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