FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term interstrand cross-link repair ID (Ontology) GO:0036297 (Gene Ontology)
Definition Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.[ PubMed:16464006 PubMed:22064477 ]
Also Known As"ICL repair"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_CELLULAR_COMPONENT
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 interstrand cross-link repair (all annotations which use CV term, excluding "NOT" statements)
     involved_in | interstrand cross-link repair
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DNA metabolic process__
DNA damage response____|
                       DNA repair
                        |__interstrand cross-link repair  16 rec.
                            |__non-recombinational interstrand cross-link repair
                            |__nucleotide-excision repair involved in interstrand cross-link repair 3 rec.
                            |__recombinational interstrand cross-link repair
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Reactome:R-HSA-6783310 "Fanconi Anemia Pathway"