FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term glutathione gamma-glutamate hydrolase ID (Ontology) GO:0036374 (Gene Ontology)
Definition Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate.[ EC:3 ]
Also Known As "glutathione hydrolase activity"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       4
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 glutathione gamma-glutamate hydrolase (all annotations which use CV term, excluding "NOT" statements)       1      4
     enables | glutathione gamma-glutamate hydrolase       --       4
Spanning Tree (Parents/Children)
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peptidase activity
 |__omega peptidase activity___________
 |__threonine-type peptidase activity__|
                                       glutathione gamma-glutamate hydrolase  5 rec.
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Is a omega peptidase activity
threonine-type peptidase activity
Part of
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Synonyms
  • "gamma-glutamyltranspeptidase activity" RELATED[ EC:3 ]
    "glutathionase activity" RELATED[ EC:3 ]
    "glutathione hydrolase activity" EXACT
Secondary IDs
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EC:3.4.19.13
KEGG_REACTION:R00494
MetaCyc:RXN-12618
Reactome:R-HSA-1222712 "Nitrosoglutathione gets cleaved to Cys(NO)-Gly"
Reactome:R-HSA-266046 "GGT1, 5 dimers hydrolyse LTC4 to LTD4"
Reactome:R-HSA-5433072 "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG"
Reactome:R-HSA-5602984 "Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG"
Reactome:R-HSA-8943279 "GGT dimers hydrolyse GSH"
Reactome:R-HSA-9026757 "GGT hydrolyses MCTR1 to MCTR2"
Reactome:R-HSA-9026907 "GGT hydrolyses PCTR2 to PCTR3"
Reactome:R-HSA-9026912 "GGT hydrolyses PCTR1 to PCTR2"
Reactome:R-HSA-9026916 "GGT hydrolyses RCTR2 to RCTR3"
Reactome:R-HSA-9026927 "GGT hydrolyses RCTR1 to RCTR2"
Reactome:R-HSA-9035966 "Defective GGT1 does not hydrolyse GSH"
Reactome:R-HSA-9753634 "GGT dimers hydrolyse APAP-SG"
RHEA:28807