FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term RNA N6-methyladenosine methyltransferase complex ID (Ontology) GO:0036396 (Gene Ontology)
Definition A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).[ PubMed:22685417 PubMed:24316715 PubMed:24407421 PubMed:29507755 PubMed:29535189 PubMed:29547716 ]
Also Known As"Mum2, Ime4, and Slz1 complex" ; "WMM complex"
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Genes (FBgn)GO_CELLULAR_COMPONENT
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 RNA N6-methyladenosine methyltransferase complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | RNA N6-methyladenosine methyltransferase complex       --
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intracellular anatomical structure__
transferase complex_________________|
                                    methyltransferase complex
                                     |__RNA N6-methyladenosine methyltransferase complex  8 rec.
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Is a methyltransferase complex
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Synonyms
  • "m(6)A writer complex" RELATED
    "m6A methyltransferase complex" RELATED
    "METTL3-METTL14-WTAP methyltransferase complex" RELATED
    "MIS complex" RELATED
    "Mum2, Ime4, and Slz1 complex" EXACT[ PubMed:22685417 ]
    "WMM complex" EXACT
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