FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term IRE1-mediated unfolded protein response ID (Ontology) GO:0036498 (Gene Ontology)
Definition The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.[ PubMed:22013210 ]
Also Known As "endoplasmic reticulum unfolded protein response; IRE1 signaling" ; "IRE1 branch of UPR" ; "UPR signaling by IRE1 stress sensor"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 IRE1-mediated unfolded protein response (all annotations which use CV term, excluding "NOT" statements)
     involved_in | IRE1-mediated unfolded protein response
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cellular response to unfolded protein_____
response to endoplasmic reticulum stress__|
intracellular signal transduction_________|
                                          endoplasmic reticulum unfolded protein response
                                           |__IRE1-mediated unfolded protein response  4 rec.
                                               |__regulation of IRE1-mediated unfolded protein response 2 rec.
                                                   |__negative regulation of IRE1-mediated unfolded protein response 1 rec.
                                                   |__positive regulation of IRE1-mediated unfolded protein response
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Is a endoplasmic reticulum unfolded protein response
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Synonyms
  • "endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT
    "ERN1-mediated unfolded protein response" RELATED
    "inositol-requiring enzyme 1-mediated unfolded protein response" RELATED
    "inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED[ PubMed:22013210 ]
    "IRE1 branch of UPR" EXACT
    "IRE1 signal transduction pathway" BROAD
    "IRE1 signaling in response to endoplasmic reticulum stress" RELATED
    "IRE1alpha unfolded protein response" NARROW[ PubMed:22013210 ]
    "IRE1p unfolded protein response" NARROW[ PubMed:22013210 ]
    "UPR signaling by IRE1 stress sensor" EXACT
Secondary IDs
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Reactome:R-HSA-381070 "IRE1alpha activates chaperones"