FB2026_02 , released June 18, 2026

CV Term Report

Help Close All Open All

General Information

Term

nitric oxide-cGMP-mediated signaling

ID (Ontology)

GO:0038060 (Gene Ontology)

Definition

An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP.[ PubMed:21549190 PubMed:22019632 ]

Also Known As

"canonical nitric oxide signaling" ; "classical nitric oxide signaling" ; "nitric oxide-cGMP-mediated signal transduction" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
nitric oxide-cGMP-mediated signaling (all annotations which use CV term, excluding "NOT" statements)
involved_in \| nitric oxide-cGMP-mediated signaling

Spanning Tree (Parents/Children)

  intracellular signal transduction
   |__intracellular signaling cassette
       |__nitric oxide-cGMP-mediated signaling  4 rec.
           |__regulation of nitric oxide-cGMP mediated signal transduction
               |__negative regulation of nitric oxide-cGMP mediated signal transduction
               |__positive regulation of nitric oxide-cGMP mediated signal transduction

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	intracellular signaling cassette
Part of
Synonyms & Secondary IDs
Synonyms
	"canonical nitric oxide signaling" EXACT "classical nitric oxide signaling" EXACT[ PubMed:21549190 ] "nitric oxide-cGMP-mediated signal transduction" EXACT "nitric oxide-cGMP-mediated signaling pathway" EXACT "nitric oxide-cGMP-mediated signalling pathway" EXACT "NO-cGMP signaling pathway" EXACT[ PubMed:22019632 ]
Secondary IDs

External Crossreferences & Linkouts