FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term nitric oxide-cGMP-mediated signaling ID (Ontology) GO:0038060 (Gene Ontology)
Definition An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP.[ PubMed:21549190 PubMed:22019632 ]
Also Known As "canonical nitric oxide signaling" ; "classical nitric oxide signaling" ; "nitric oxide-cGMP-mediated signal transduction" (for all, see Synonyms field below)
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       4
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 Genes
 nitric oxide-cGMP-mediated signaling (all annotations which use CV term, excluding "NOT" statements)       4
     involved_in | nitric oxide-cGMP-mediated signaling       4
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  intracellular signal transduction
   |__intracellular signaling cassette
       |__nitric oxide-cGMP-mediated signaling  4 rec.
           |__regulation of nitric oxide-cGMP mediated signal transduction
               |__negative regulation of nitric oxide-cGMP mediated signal transduction
               |__positive regulation of nitric oxide-cGMP mediated signal transduction
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Is a intracellular signaling cassette
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Synonyms
  • "canonical nitric oxide signaling" EXACT
    "classical nitric oxide signaling" EXACT[ PubMed:21549190 ]
    "nitric oxide-cGMP-mediated signal transduction" EXACT
    "nitric oxide-cGMP-mediated signaling pathway" EXACT
    "nitric oxide-cGMP-mediated signalling pathway" EXACT
    "NO-cGMP signaling pathway" EXACT[ PubMed:22019632 ]
Secondary IDs
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