FB2026_03 , released September 17, 2026
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Term epigenetic regulation of gene expression ID (Ontology) GO:0040029 (Gene Ontology)
Definition A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal.[ PubMed:10521337 PubMed:11498582 PubMed:22243696 PubMed:34414474 ]
Also Known As"regulation of gene expression, epigenetic"
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 epigenetic regulation of gene expression (all annotations which use CV term, excluding "NOT" statements)
     involved_in | epigenetic regulation of gene expression       --
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chromatin organization
 |__chromatin remodeling__________________________
gene expression                                   |
 |__regulation of gene expression_________________|
regulation of macromolecule biosynthetic process  |
 |__regulation of gene expression_________________|
                                                  epigenetic regulation of gene expression  235 rec.
                                                   |__epigenetic programming of gene expression 2 rec.
                                                   |   |__epigenetic programming in the zygotic pronuclei(+)
                                                   |   |__genomic imprinting(+) 1 rec.
                                                   |__negative regulation of gene expression, epigenetic 194 rec.
                                                   |   |__heterochromatin formation(+) 190 rec.
                                                   |   |__negative regulation of gene expression via chromosomal CpG island methylation
                                                   |__positive regulation of gene expression, epigenetic 17 rec.
                                                   |   |__chromosomal 5-methylcytosine DNA demethylation, oxidation pathway
                                                   |   |__transcription initiation-coupled chromatin remodeling(+) 16 rec.
                                                   |__sex-chromosome dosage compensation 27 rec.
                                                       |__dosage compensation by hyperactivation of X chromosome 25 rec.
                                                       |__dosage compensation by hypoactivation of X chromosome
                                                       |__dosage compensation by inactivation of X chromosome(+)
                                                       |__dosage compensation complex assembly 2 rec.
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Is a chromatin remodeling
regulation of gene expression
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Reactome:R-HSA-212165 "Epigenetic regulation of gene expression"
Reactome:R-HSA-8986944 "Transcriptional Regulation by MECP2"