FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term histone methyltransferase activity ID (Ontology) GO:0042054 (Gene Ontology)
Definition Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue.
Also Known As "histone methylase activity" ; "histone N-methyltransferase activity"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      12
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 histone methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)      12
     enables | histone methyltransferase activity      12
 NOT | enables | histone methyltransferase activity       1
Spanning Tree (Parents/Children)
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methyltransferase activity
 |__protein methyltransferase activity___
catalytic activity, acting on a protein  |
 |__protein methyltransferase activity___|
 |__histone modifying activity___________|
                                         histone methyltransferase activity  39 rec.
                                          |__histone H1 methyltransferase activity
                                          |   |__H1-4K26 methyltransferase activity
                                          |__histone H2A methyltransferase activity 2 rec.
                                          |   |__histone H2AQ104 methyltransferase activity 2 rec.
                                          |   |__histone H2AR3 methyltransferase activity
                                          |__histone H3 methyltransferase activity 30 rec.
                                          |   |__histone H3K4 methyltransferase activity(+) 17 rec.
                                          |   |__histone H3K9 methyltransferase activity(+) 8 rec.
                                          |   |__histone H3K27 methyltransferase activity(+) 4 rec.
                                          |   |__histone H3K36 methyltransferase activity(+) 6 rec.
                                          |   |__histone H3K37 methyltransferase activity
                                          |   |__histone H3K56 methyltransferase activity
                                          |   |__histone H3K79 methyltransferase activity(+) 1 rec.
                                          |   |__histone H3R2 methyltransferase activity 2 rec.
                                          |   |__histone H3R8 methyltransferase activity
                                          |   |__histone H3R17 methyltransferase activity 2 rec.
                                          |   |__histone H3R26 methyltransferase activity
                                          |__histone H4 methyltransferase activity 6 rec.
                                              |__histone H4K12 methyltransferase activity 1 rec.
                                              |__histone H4K20 methyltransferase activity(+) 3 rec.
                                              |__histone H4R3 methyltransferase activity 1 rec.
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Is a protein methyltransferase activity
histone modifying activity
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Synonyms
  • "histone methylase activity" EXACT
    "histone N-methyltransferase activity" EXACT
Secondary IDs
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Reactome:R-HSA-5205861 "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)"
Reactome:R-HSA-5216234 "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)"
Reactome:R-HSA-9822583 "METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)"
RHEA:10024
RHEA:60312
RHEA:67112
RHEA:67808