FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

error-prone translesion synthesis

ID (Ontology)

GO:0042276 (Gene Ontology)

Definition

The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.[ PubMed:11485998 ]

Also Known As

"mutagenic PRR"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
error-prone translesion synthesis (all annotations which use CV term, excluding "NOT" statements)
involved_in \| error-prone translesion synthesis
NOT \| involved_in \| error-prone translesion synthesis

Spanning Tree (Parents/Children)

DNA damage tolerance_______________________
DNA synthesis involved in DNA replication__|
                                           translesion synthesis
                                            |__error-prone translesion synthesis  2 rec.
                                                |__regulation of error-prone translesion synthesis
                                                    |__negative regulation of error-prone translesion synthesis
                                                    |__positive regulation of error-prone translesion synthesis

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	translesion synthesis
Part of
Synonyms & Secondary IDs
Synonyms
	"error-prone postreplication DNA repair" RELATED "mutagenic postreplication DNA repair" RELATED "mutagenic PRR" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-110312 "Translesion synthesis by REV1" Reactome:R-HSA-5655862 "Translesion synthesis by POLK" Reactome:R-HSA-5656121 "Translesion synthesis by POLI"