FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term TIM22 mitochondrial import inner membrane insertion complex ID (Ontology) GO:0042721 (Gene Ontology)
Definition A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12.[ PubMed:12191765 PubMed:27554484 ]
Also Known As"mitochondrial inner membrane protein insertion complex" ; "Tim22 complex"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_CELLULAR_COMPONENT
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 TIM22 mitochondrial import inner membrane insertion complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | TIM22 mitochondrial import inner membrane insertion complex       --
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mitochondrial inner membrane______________
membrane protein complex__________________|
mitochondrial protein-containing complex__|
                                          inner mitochondrial membrane protein complex
                                           |__TIM22 mitochondrial import inner membrane insertion complex  8 rec.
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Is a inner mitochondrial membrane protein complex
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Synonyms
  • "mitochondrial inner membrane protein insertion complex" EXACT
    "mitochondrial protein translocase complex" BROAD
    "Tim22 complex" EXACT
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