FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

ecdysteroid 22-hydroxylase activity

ID (Ontology)

GO:0042767 (Gene Ontology)

Definition

Catalysis of the reaction: 3-dehydro-2,22-dideoxyecdysone + 2 reduced [adrenodoxin] + O2 + 2 H+ = 3-dehydro-2-deoxyecdysone + 2 oxidized [adrenodoxin] + H2O. Other substrates include 3-dehydro-2,22,25-deoxyecdysone and 2,22-dideoxyecdysone.[ EC:1 PubMed:12177427 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
ecdysteroid 22-hydroxylase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| ecdysteroid 22-hydroxylase activity

Spanning Tree (Parents/Children)

monooxygenase activity
 |__steroid hydroxylase activity_________________________________________________________________________________________
 |__oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen__|
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen                                                                                         |
 |__oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen__|
                                                                                         ecdysteroid 22-hydroxylase activity  1 rec.

Spanning Tree View Settings
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Relationships
Is a	steroid hydroxylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
Part of
Synonyms & Secondary IDs
Synonyms
	"3-dehydro-2,22-dideoxyecdysone 22-hydroxylase activity" NARROW[ EC:1 ]
Secondary IDs

External Crossreferences & Linkouts
	EC:1.14.15.44 MetaCyc:RXN-14678 MetaCyc:RXN-14681 MetaCyc:RXN-24931 RHEA:82055 RHEA:83295 RHEA:83299