FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term histone H4K20 methyltransferase activity ID (Ontology) GO:0042799 (Gene Ontology)
Definition Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein.[ PubMed:12086618 ]
Also Known As"histone H4 lysine 20-specific methyltransferase activity" ; "histone H4K20 methylation" ; "histone lysine N-methyltransferase activity (H4-K20 specific)" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 histone H4K20 methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | histone H4K20 methyltransferase activity
 NOT | enables | histone H4K20 methyltransferase activity
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protein methyltransferase activity
 |__protein-lysine N-methyltransferase activity__
lysine N-methyltransferase activity              |
 |__protein-lysine N-methyltransferase activity__|
histone methyltransferase activity               |
 |__histone H4 methyltransferase activity________|
                                                 histone H4K20 methyltransferase activity  4 rec.
                                                  |__histone H4K20 monomethyltransferase activity 1 rec.
                                                  |__histone H4K20 trimethyltransferase activity 1 rec.
                                                  |__histone H4K20me methyltransferase activity 1 rec.
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Is a protein-lysine N-methyltransferase activity
histone H4 methyltransferase activity
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Synonyms
  • "histone H4 lysine 20-specific methyltransferase activity" EXACT
    "histone H4K20 methylase activity" BROAD
    "histone H4K20 methylation" EXACT
    "histone lysine N-methyltransferase activity (H4-K20 specific)" EXACT
    "histone methylase activity (H4-K20 specific)" EXACT
    "histone methyltransferase activity (H4-K20 specific)" EXACT
    "histone-H4K20 methyltransferase activity" EXACT
Secondary IDs
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Reactome:R-HSA-2301205 "SETD8 monomethylates histone H4"
Reactome:R-HSA-5682965 "WHSC1 dimethylates histone H4 on lysine K21 at DSBs"