FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term histone H3K4 methyltransferase activity ID (Ontology) GO:0042800 (Gene Ontology)
Definition Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein.[ PubMed:12086618 ]
Also Known As "histone H3 lysine 4-specific methyltransferase activity" ; "histone H3K4 methylase activity" ; "histone lysine N-methyltransferase activity (H3-K4 specific)" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 histone H3K4 methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | histone H3K4 methyltransferase activity       --
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protein methyltransferase activity
 |__protein-lysine N-methyltransferase activity__
lysine N-methyltransferase activity              |
 |__protein-lysine N-methyltransferase activity__|
histone methyltransferase activity               |
 |__histone H3 methyltransferase activity________|
                                                 histone H3K4 methyltransferase activity  17 rec.
                                                  |__histone H3K4 dimethyltransferase activity 3 rec.
                                                  |__histone H3K4 monomethyltransferase activity 2 rec.
                                                  |__histone H3K4 trimethyltransferase activity 3 rec.
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Is a protein-lysine N-methyltransferase activity
histone H3 methyltransferase activity
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Synonyms
  • "histone H3 lysine 4-specific methyltransferase activity" EXACT
    "histone H3K4 methylase activity" EXACT
    "histone lysine N-methyltransferase activity (H3-K4 specific)" EXACT
    "histone methylase activity (H3-K4 specific)" EXACT
    "histone methyltransferase activity (H3-K4 specific)" EXACT
    "histone-H3K4 methyltransferase activity" EXACT
Secondary IDs
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Reactome:R-HSA-1214188 "PRDM9 trimethylates histone H3"
Reactome:R-HSA-3364026 "MLL2 complex trimethylates H3K4 at the MYC gene"
Reactome:R-HSA-8865498 "KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark"
Reactome:R-HSA-8936481 "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter"
Reactome:R-HSA-8936621 "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter"
Reactome:R-HSA-8937016 "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter"
Reactome:R-HSA-8937050 "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter"
Reactome:R-HSA-9843121 "MLL4-ASCOM, (MLL3-ASCOM) complex monomethylates nucleosomes at PPARG:RXRA-bound enhancers"
Reactome:R-HSA-9909628 "Trimethylation of CD274 gene chromatin by MLL1/3 complex"