FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

replication fork arrest

ID (Ontology)

GO:0043111 (Gene Ontology)

Definition

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected.[ PubMed:14645529 ]

Also Known As

"negative regulation of DNA replication at replication fork barrier" ; "replication fork blocking" ; "replication fork stalling"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
replication fork arrest (all annotations which use CV term, excluding "NOT" statements)
involved_in \| replication fork arrest

Spanning Tree (Parents/Children)

DNA metabolic process
 |__DNA-templated DNA replication maintenance of fidelity__
DNA-templated DNA replication                              |
 |__DNA-templated DNA replication maintenance of fidelity__|
negative regulation of DNA replication                     |
 |__negative regulation of DNA-templated DNA replication___|
regulation of DNA-templated DNA replication                |
 |__negative regulation of DNA-templated DNA replication___|
                                                           replication fork arrest  4 rec.
                                                            |__replication fork arrest at mating type locus
                                                            |__replication fork arrest at rDNA repeats
                                                            |   |__regulation of replication fork arrest at rDNA repeats
                                                            |__replication fork arrest at tRNA locus
                                                            |__replication fork arrest involved in DNA replication termination 1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	DNA-templated DNA replication maintenance of fidelity negative regulation of DNA-templated DNA replication
Part of
Synonyms & Secondary IDs
Synonyms
	"negative regulation of DNA replication at replication fork barrier" EXACT "replication fork blocking" EXACT "replication fork stalling" EXACT
Secondary IDs

External Crossreferences & Linkouts