FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

negative regulation of MAPK cascade

ID (Ontology)

GO:0043409 (Gene Ontology)

Definition

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.

Also Known As

"down regulation of MAPK cascade" ; "down regulation of MAPKKK cascade" ; "down-regulation of MAPK cascade" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
negative regulation of MAPK cascade (all annotations which use CV term, excluding "NOT" statements)
involved_in \| negative regulation of MAPK cascade

Spanning Tree (Parents/Children)

MAPK cascade
 |__regulation of MAPK cascade________________________________
negative regulation of signal transduction                    |
 |__negative regulation of intracellular signal transduction__|
regulation of intracellular signal transduction               |
 |__regulation of MAPK cascade________________________________|
 |__negative regulation of intracellular signal transduction__|
                                                              negative regulation of MAPK cascade  54 rec.
                                                               |__negative regulation of ERK1 and ERK2 cascade 23 rec.
                                                               |__negative regulation of ERK5 cascade
                                                               |__negative regulation of JNK cascade 29 rec.
                                                               |   |__negative regulation of JUN kinase activity 1 rec.
                                                               |__negative regulation of MAP kinase activity 1 rec.
                                                               |   |__negative regulation of JUN kinase activity 1 rec.
                                                               |__negative regulation of p38MAPK cascade
                                                               |__negative regulation of pheromone response MAPK cascade
                                                               |__negative regulation of stress-activated MAPK cascade 2 rec.
                                                                   |__negative regulation of cell integrity MAPK cascade

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	regulation of MAPK cascade negative regulation of intracellular signal transduction
Part of
Synonyms & Secondary IDs
Synonyms
	"down regulation of MAPK cascade" EXACT "down regulation of MAPKKK cascade" EXACT "down-regulation of MAPK cascade" EXACT "down-regulation of MAPKKK cascade" EXACT "downregulation of MAPK cascade" EXACT "downregulation of MAPKKK cascade" EXACT "inhibition of MAPK cascade" NARROW "inhibition of MAPKKK cascade" NARROW "negative regulation of MAP kinase cascade" EXACT "negative regulation of MAP kinase kinase kinase cascade" EXACT "negative regulation of MAPKKK cascade" EXACT "negative regulation of mitogen activated protein kinase cascade" EXACT "negative regulation of mitogen activated protein kinase kinase kinase cascade" EXACT "negative regulation of mitogen-activated protein kinase cascade" EXACT "negative regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT
Secondary IDs

External Crossreferences & Linkouts