FB2026_03 , released September 17, 2026
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Term macromolecule modification ID (Ontology) GO:0043412 (Gene Ontology)
Definition The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.
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 macromolecule modification (all annotations which use CV term, excluding "NOT" statements)
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  metabolic process
   |__macromolecule metabolic process
       |__macromolecule modification  608 rec.
           |__DNA modification 1 rec.
           |   |__base J metabolic process
           |   |__depurination
           |   |__depyrimidination
           |   |__DNA ADP-ribosylation
           |   |__DNA dealkylation
           |   |__DNA deamination(+)
           |   |__DNA restriction-modification system
           |__macromolecule deacylation 1 rec.
           |   |__macromolecule depalmitoylation(+)
           |   |__protein deacylation(+) 1 rec.
           |__macromolecule methylation 60 rec.
           |   |__protein methylation(+) 6 rec.
           |   |__RNA methylation(+) 54 rec.
           |__protein modification process 489 rec.
           |   |__actin modification(+) 1 rec.
           |   |__metal incorporation into metallo-molybdopterin complex(+)
           |   |__metal incorporation into metallo-sulfur cluster(+)
           |   |__N-terminal protein amino acid modification(+) 12 rec.
           |   |__nucleic acid-protein covalent cross-linking(+)
           |   |__peptide cross-linking(+)
           |   |__peptidyl-arginine modification(+) 1 rec.
           |   |__peptidyl-glutamic acid modification(+) 6 rec.
           |   |__peptidyl-glycine modification(+)
           |   |__peptidyl-lysine modification(+) 31 rec.
           |   |__peptidyl-methionine modification(+) 2 rec.
           |   |__peptidyl-phenylalanine modification
           |   |__peptidyl-proline modification(+) 5 rec.
           |   |__post-translational protein modification(+) 355 rec.
           |   |__protein acylation(+) 13 rec.
           |   |__protein alkylation(+) 6 rec.
           |   |__protein arginylation
           |   |__protein carbamoylation
           |   |__protein carboxylation(+)
           |   |__protein de-ADP-ribosylation(+)
           |   |__protein deacylation(+) 1 rec.
           |   |__protein dealkylation(+)
           |   |__protein deamination
           |   |__protein deglutathionylation
           |   |__protein deglycation(+)
           |   |__protein deglycosylation(+) 3 rec.
           |   |__protein dehydration
           |   |__protein delipidation
           |   |__protein denucleotidylation(+) 1 rec.
           |   |__protein dephosphorylation(+) 20 rec.
           |   |__protein flavinylation
           |   |__protein glutathionylation(+)
           |   |__protein histidyl modification to diphthamide 8 rec.
           |   |__protein hydroxylation(+) 3 rec.
           |   |__protein lipidation(+) 1 rec.
           |   |__protein nitrosylation(+)
           |   |__protein nucleotidylation(+) 1 rec.
           |   |__protein oxidation(+)
           |   |__protein phosphopantetheinylation(+)
           |   |__protein phosphorylation(+) 64 rec.
           |   |__protein polyamination
           |   |__protein prenylation(+)
           |   |__protein sialylation
           |   |__protein sulfation(+)
           |   |__protein sulfhydration(+)
           |   |__protein-coenzyme A linkage(+)
           |   |__protein-FAD linkage 2 rec.
           |   |__protein-pyridoxal-5-phosphate linkage(+)
           |   |__regulation of protein modification process(+) 43 rec.
           |__RNA modification 120 rec.
           |   |__base conversion or substitution editing(+) 3 rec.
           |   |__chloroplast RNA modification(+)
           |   |__mitochondrial RNA modification(+) 14 rec.
           |   |__mRNA modification(+) 12 rec.
           |   |__oxidative RNA demethylation 1 rec.
           |   |__pseudouridine synthesis(+) 16 rec.
           |   |__RNA acetylation(+) 2 rec.
           |   |__RNA methylation(+) 54 rec.
           |   |__RNA nucleotide deletion(+)
           |   |__RNA nucleotide insertion(+)
           |   |__rRNA modification(+) 31 rec.
           |   |__snRNA modification(+) 9 rec.
           |   |__tRNA modification(+) 73 rec.
           |__sialylation 2 rec.
               |__protein sialylation
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