FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

negative regulation of DNA damage response, signal transduction by p53 class mediator

ID (Ontology)

GO:0043518 (Gene Ontology)

Definition

Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.

Also Known As

"down regulation of DNA damage response, signal transduction by p53 class mediator" ; "down-regulation of DNA damage response, signal transduction by p53 class mediator" ; "downregulation of DNA damage response, signal transduction by p53 class mediator" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
negative regulation of DNA damage response, signal transduction by p53 class mediator (all annotations which use CV term, excluding "NOT" statements)
involved_in \| negative regulation of DNA damage response, signal transduction by p53 class mediator

Spanning Tree (Parents/Children)

DNA damage response, signal transduction by p53 class mediator
 |__regulation of DNA damage response, signal transduction by p53 class mediator__
regulation of cellular response to stress                                         |
 |__regulation of DNA damage response, signal transduction by p53 class mediator__|
regulation of signal transduction by p53 class mediator                           |
 |__regulation of DNA damage response, signal transduction by p53 class mediator__|
 |__negative regulation of signal transduction by p53 class mediator______________|
negative regulation of intracellular signal transduction                          |
 |__negative regulation of signal transduction by p53 class mediator______________|
                                                                                  negative regulation of DNA damage response, signal transduction by p53 class mediator  1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of signal transduction by p53 class mediator
Part of
Synonyms & Secondary IDs
Synonyms
	"down regulation of DNA damage response, signal transduction by p53 class mediator" EXACT "down-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT "downregulation of DNA damage response, signal transduction by p53 class mediator" EXACT "inhibition of DNA damage response, signal transduction by p53 class mediator" NARROW "negative regulation of p53 induced by DNA damage response" EXACT
Secondary IDs

External Crossreferences & Linkouts