FB2026_03 , released September 17, 2026

CV Term Report

Help Close All Open All

General Information

Term

insulin receptor substrate binding

ID (Ontology)

GO:0043560 (Gene Ontology)

Definition

Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.[ PubMed:12829233 ]

Also Known As

"insulin receptor substrate [protein] binding" ; "IRS [protein] binding" ; "IRS binding"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
insulin receptor substrate binding (all annotations which use CV term, excluding "NOT" statements)
enables \| insulin receptor substrate binding

Spanning Tree (Parents/Children)

  binding
   |__protein binding
       |__insulin receptor substrate binding  1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein binding
Part of
Synonyms & Secondary IDs
Synonyms
	"insulin receptor substrate [protein] binding" EXACT "IRS [protein] binding" EXACT "IRS binding" EXACT
Secondary IDs

External Crossreferences & Linkouts