FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

PCNA complex

ID (Ontology)

GO:0043626 (Gene Ontology)

Definition

A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.[ PubMed:12829735 ]

Also Known As

"PCNA homotrimer" ; "proliferating cell nuclear antigen complex"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
PCNA complex (all annotations which use CV term, excluding "NOT" statements)
part_of \| PCNA complex

Spanning Tree (Parents/Children)

nucleus
 |__nuclear protein-containing complex__________
protein-containing complex                      |
 |__nuclear protein-containing complex__________|
enzyme activator complex                        |
 |__DNA polymerase processivity factor complex__|
                                                PCNA complex  2 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	DNA polymerase processivity factor complex nuclear protein-containing complex
Part of
Synonyms & Secondary IDs
Synonyms
	"PCNA homotrimer" EXACT "proliferating cell nuclear antigen complex" EXACT "sliding clamp" BROAD
Secondary IDs

External Crossreferences & Linkouts