FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

mitochondria-associated endoplasmic reticulum membrane contact site

ID (Ontology)

GO:0044233 (Gene Ontology)

Definition

A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange.[ PubMed:19556461 PubMed:22078959 PubMed:29626751 PubMed:29684109 ]

Also Known As

"endoplasmic reticulum-mitochondrion membrane contact site" ; "ER-mitochondrion membrane contact site" ; "mitochondria-associated ER membrane" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Alleles	Genes	Constructs
mitochondria-associated endoplasmic reticulum membrane contact site (all annotations which use CV term, excluding "NOT" statements)	--		--
is_active_in \| mitochondria-associated endoplasmic reticulum membrane contact site	--		--
located_in \| mitochondria-associated endoplasmic reticulum membrane contact site	--		--
mitochondria-associated endoplasmic reticulum membrane contact site \| increased number \| larval stage		--

Spanning Tree (Parents/Children)

organelle______________________
cellular anatomical structure__|
                               organelle membrane contact site
                                |__mitochondria-associated endoplasmic reticulum membrane contact site  5 rec.
                                    |__ERMES complex

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	organelle membrane contact site
Part of
Synonyms & Secondary IDs
Synonyms
	"endoplasmic reticulum-mitochondrion membrane contact site" EXACT "ER-mitochondrion membrane contact site" EXACT "MAM" RELATED "mitochondria-associated ER membrane" EXACT "mitochondria-associated membrane" EXACT "mitochondria-endoplasmic reticulum (ER) contact" EXACT[ PubMed:29870872 ]
Secondary IDs

External Crossreferences & Linkouts