FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

nuclear pore central transport channel

ID (Ontology)

GO:0044613 (Gene Ontology)

Definition

The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.[ PubMed:18046406 PubMed:19524430 PubMed:20947011 PubMed:22419078 ]

Also Known As

"nuclear pore central channel" ; "nuclear pore central plug" ; "nuclear pore transport channel"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
nuclear pore central transport channel (all annotations which use CV term, excluding "NOT" statements)
part_of \| nuclear pore central transport channel

Spanning Tree (Parents/Children)

nucleus
 |__nuclear protein-containing complex__
nuclear envelope                        |
 |__nuclear pore________________________|
protein-containing complex              |
 |__nuclear protein-containing complex__|
nuclear protein-containing complex      |
 |__nuclear pore________________________|
                                        nuclear pore central transport channel  8 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	nuclear protein-containing complex
Part of	nuclear pore
Synonyms & Secondary IDs
Synonyms
	"karyopherin docking complex" RELATED "nuclear pore central channel" EXACT "nuclear pore central plug" EXACT "nuclear pore transport channel" EXACT
Secondary IDs

External Crossreferences & Linkouts