FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term double-strand break repair via synthesis-dependent strand annealing ID (Ontology) GO:0045003 (Gene Ontology)
Definition SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break.[ PubMed:10357855 ]
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       8
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 Genes
 double-strand break repair via synthesis-dependent strand annealing (all annotations which use CV term, excluding "NOT" statements)       8
     involved_in | double-strand break repair via synthesis-dependent strand annealing       8
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recombinational repair______
double-strand break repair__|
                            double-strand break repair via homologous recombination
                             |__double-strand break repair via synthesis-dependent strand annealing  11 rec.
                                 |__DNA double-strand break processing involved in repair via synthesis-dependent strand annealing
                                 |__DNA recombinase assembly 3 rec.
                                 |   |__meiotic DNA recombinase assembly(+) 1 rec.
                                 |__heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing 1 rec.
                                 |__meiotic strand displacement involved in double-strand break repair via SDSA
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Is a double-strand break repair via homologous recombination
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Synonyms
  • "mitotic gene conversion" RELATED
    "SDSA" BROAD
Secondary IDs
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Reactome:R-HSA-5693554 "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"