FB2026_03 , released September 17, 2026
CV Term Report
Help Close All Open All
General Information
Term double-strand break repair via synthesis-dependent strand annealing ID (Ontology) GO:0045003 (Gene Ontology)
Definition SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break.[ PubMed:10357855 ]
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

    • Results list data from multiple species. Choose a record type above to open its HitList.
Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 double-strand break repair via synthesis-dependent strand annealing (all annotations which use CV term, excluding "NOT" statements)
     involved_in | double-strand break repair via synthesis-dependent strand annealing
Spanning Tree (Parents/Children)
Only view relationship:
Vocabulary search 
recombinational repair______
double-strand break repair__|
                            double-strand break repair via homologous recombination
                             |__double-strand break repair via synthesis-dependent strand annealing  11 rec.
                                 |__DNA double-strand break processing involved in repair via synthesis-dependent strand annealing
                                 |__DNA recombinase assembly 3 rec.
                                 |   |__meiotic DNA recombinase assembly(+) 1 rec.
                                 |__heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing 1 rec.
                                 |__meiotic strand displacement involved in double-strand break repair via SDSA
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a double-strand break repair via homologous recombination
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "mitotic gene conversion" RELATED
    "SDSA" BROAD
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-5693554 "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"