FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

protein targeting to ER

ID (Ontology)

GO:0045047 (Gene Ontology)

Definition

The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.[ ISBN:0716731363 ]

Also Known As

"protein targeting to endoplasmic reticulum" ; "protein-endoplasmic reticulum targeting" ; "protein-ER targeting"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
protein targeting to ER (all annotations which use CV term, excluding "NOT" statements)
involved_in \| protein targeting to ER	--

Spanning Tree (Parents/Children)

establishment of protein localization
 |__protein targeting_______________________________________________
establishment of protein localization to organelle                  |
 |__establishment of protein localization to endoplasmic reticulum__|
                                                                    protein targeting to ER  37 rec.
                                                                     |__post-translational protein targeting to endoplasmic reticulum membrane 9 rec.
                                                                     |   |__post-translational protein targeting to membrane, docking
                                                                     |   |__post-translational protein targeting to membrane, translocation(+) 6 rec.
                                                                     |__SRP-dependent cotranslational protein targeting to membrane 24 rec.
                                                                         |__SRP-dependent cotranslational protein targeting to membrane, docking 1 rec.
                                                                         |__SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 3 rec.
                                                                         |__SRP-dependent cotranslational protein targeting to membrane, translocation 13 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein targeting establishment of protein localization to endoplasmic reticulum
Part of
Synonyms & Secondary IDs
Synonyms
	"protein targeting to endoplasmic reticulum" EXACT "protein-endoplasmic reticulum targeting" EXACT "protein-ER targeting" EXACT
Secondary IDs

External Crossreferences & Linkouts