FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term protein insertion into ER membrane ID (Ontology) GO:0045048 (Gene Ontology)
Definition The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.[ ISBN:0716731363 ]
Also Known As"integral ER membrane protein localization" ; "integral ER membrane protein positioning" ; "localization of protein in ER membrane" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 protein insertion into ER membrane (all annotations which use CV term, excluding "NOT" statements)
     involved_in | protein insertion into ER membrane
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organelle organization
 |__endoplasmic reticulum organization_____________
intracellular protein localization                 |
 |__protein localization to organelle______________|
 |__protein insertion into membrane________________|
endomembrane system organization                   |
 |__endoplasmic reticulum organization_____________|
membrane organization                              |
 |__protein insertion into membrane________________|
establishment of protein localization to membrane  |
 |__protein insertion into membrane________________|
                                                   protein insertion into ER membrane  17 rec.
                                                    |__multi-pass transmembrane protein insertion into ER membrane 1 rec.
                                                    |__protein insertion into ER membrane by internal uncleaved signal-anchor sequence
                                                    |__protein insertion into ER membrane by N-terminal cleaved signal sequence
                                                    |__protein insertion into ER membrane by stop-transfer membrane-anchor sequence 3 rec.
                                                    |__tail-anchored membrane protein insertion into ER membrane 13 rec.
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Is a protein insertion into membrane
Part of endoplasmic reticulum organization
protein localization to organelle
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Synonyms
  • "integral ER membrane protein localization" EXACT
    "integral ER membrane protein positioning" EXACT
    "localization of protein in ER membrane" EXACT
    "positioning of protein in ER membrane" EXACT
    "protein insertion into endoplasmic reticulum membrane" EXACT
    "protein-endoplasmic reticulum insertion" EXACT
    "protein-ER insertion" EXACT
Secondary IDs
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Reactome:R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"