FB2026_03 , released September 17, 2026
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Term alpha-ketoacid dehydrogenase complex ID (Ontology) GO:0045240 (Gene Ontology)
Definition A multi-enzyme complex that catalyzes the oxidative decarboxylation of an alpha-ketoacid - pyruvate, a branched-chain alpha-ketoacid or alpha-ketoglutarate (also known as 2-oxoglutarate). The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: a dihydrolipoyl transacylase (E2) forms the core of the complex, with an alpha-ketoacid dehydrogenase (E1) and a dihydrolipoamide dehydrogenase (E3) attached through non-covalent bonds. The E1 and E2 components are specific to different alpha-ketoacid dehydrogenase complexes, whereas the E3 component is the same. Additional proteins may also be present.[ PubMed:10745006 ]
Also Known As"2-oxoacid dehydrogenase complex" ; "dihydrolipoyl dehydrogenase complex"
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 alpha-ketoacid dehydrogenase complex (all annotations which use CV term, excluding "NOT" statements)
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  catalytic complex
   |__oxidoreductase complex
       |__alpha-ketoacid dehydrogenase complex  28 rec.
           |__branched-chain alpha-ketoacid dehydrogenase complex 6 rec.
           |__oxoadipate dehydrogenase complex 5 rec.
           |__oxoglutarate dehydrogenase complex 8 rec.
           |__pyruvate dehydrogenase complex 12 rec.
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Is a oxidoreductase complex
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  • "2-oxoacid dehydrogenase complex" EXACT
    "dihydrolipoyl dehydrogenase complex" EXACT
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