FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term oxoglutarate dehydrogenase complex ID (Ontology) GO:0045252 (Gene Ontology)
Definition A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.[ PubMed:10672230 ]
Also Known As "alpha-ketoglutarate dehydrogenase complex" ; "dihydrolipoamide S-succinyltransferase complex" ; "KGDHC"
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Genes (FBgn)GO_CELLULAR_COMPONENT
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 oxoglutarate dehydrogenase complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | oxoglutarate dehydrogenase complex       --
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cytoplasm
 |__tricarboxylic acid cycle heteromeric enzyme complex__
catalytic complex                                        |
 |__tricarboxylic acid cycle heteromeric enzyme complex__|
 |__transferase complex__________________________________|
oxidoreductase complex                                   |
 |__alpha-ketoacid dehydrogenase complex_________________|
                                                         oxoglutarate dehydrogenase complex  8 rec.
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Is a tricarboxylic acid cycle heteromeric enzyme complex
alpha-ketoacid dehydrogenase complex
transferase complex
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Synonyms
  • "alpha-ketoglutarate dehydrogenase complex" EXACT
    "dihydrolipoamide S-succinyltransferase complex" EXACT
    "KGDHC" EXACT
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Wikipedia:Oxoglutarate_dehydrogenase_complex