FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term pyruvate dehydrogenase complex ID (Ontology) GO:0045254 (Gene Ontology)
Definition A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.[ PubMed:36863425 ]
Also Known As "pyruvate dehydrogenase complex (lipoamide)"
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Genes (FBgn)GO_CELLULAR_COMPONENT
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 pyruvate dehydrogenase complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | pyruvate dehydrogenase complex       --
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oxidoreductase complex
 |__alpha-ketoacid dehydrogenase complex__
transferase complex                       |
 |__acetyltransferase complex_____________|
                                          pyruvate dehydrogenase complex  12 rec.
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Is a alpha-ketoacid dehydrogenase complex
acetyltransferase complex
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Wikipedia:Pyruvate_dehydrogenase_complex