FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

negative regulation of gene expression, epigenetic

ID (Ontology)

GO:0045814 (Gene Ontology)

Definition

An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation.[ PubMed:22243696 ]

Also Known As

"down regulation of gene expression, epigenetic" ; "down-regulation of gene expression, epigenetic" ; "downregulation of gene expression, epigenetic"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
negative regulation of gene expression, epigenetic (all annotations which use CV term, excluding "NOT" statements)
involved_in \| negative regulation of gene expression, epigenetic

Spanning Tree (Parents/Children)

chromatin remodeling
 |__epigenetic regulation of gene expression_______________
regulation of gene expression                              |
 |__negative regulation of gene expression_________________|
 |__epigenetic regulation of gene expression_______________|
negative regulation of macromolecule biosynthetic process  |
 |__negative regulation of gene expression_________________|
                                                           negative regulation of gene expression, epigenetic  194 rec.
                                                            |__heterochromatin formation 190 rec.
                                                            |   |__constitutive heterochromatin formation(+) 46 rec.
                                                            |   |__dosage compensation by inactivation of X chromosome(+)
                                                            |   |__facultative heterochromatin formation(+) 8 rec.
                                                            |   |__heterochromatin boundary formation 11 rec.
                                                            |   |__regulation of heterochromatin formation(+) 23 rec.
                                                            |   |__regulatory ncRNA-mediated heterochromatin formation(+) 35 rec.
                                                            |__negative regulation of gene expression via chromosomal CpG island methylation

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	negative regulation of gene expression epigenetic regulation of gene expression
Part of
Synonyms & Secondary IDs
Synonyms
	"down regulation of gene expression, epigenetic" EXACT "down-regulation of gene expression, epigenetic" EXACT "downregulation of gene expression, epigenetic" EXACT "gene silencing" RELATED "inhibition of gene expression, epigenetic" NARROW
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-212300 "PRC2 methylates histones and DNA" Reactome:R-HSA-5250941 "Negative epigenetic regulation of rRNA expression"