FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity ID (Ontology) GO:0046934 (Gene Ontology)
Definition Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + H+.[ EC:2 ]
Also Known As"phosphatidylinositol-4,5-bisphosphate 3-kinase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
 NOT | enables | 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
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lipid kinase activity___________________________________
phosphotransferase activity, alcohol group as acceptor__|
                                                        phosphatidylinositol kinase activity
                                                         |__1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity  1 rec.
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Is a phosphatidylinositol kinase activity
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Synonyms
  • "phosphatidylinositol 3-kinase activity, class I" NARROW
    "phosphatidylinositol 3-kinase activity, class II" NARROW
    "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW
    "phosphatidylinositol-4,5-bisphosphate 3-kinase activity" EXACT
    "type I phosphoinositide 3-kinase activity" NARROW[ EC:2 ]
Secondary IDs
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EC:2.7.1.153
KEGG_REACTION:R04545
MetaCyc:2.7.1.153-RXN
Reactome:R-HSA-1226014 "Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants"
Reactome:R-HSA-1250370 "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers"
Reactome:R-HSA-1250462 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3"
Reactome:R-HSA-1306957 "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR"
Reactome:R-HSA-1306979 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1"
Reactome:R-HSA-1676048 "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane"
Reactome:R-HSA-177939 "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)"
Reactome:R-HSA-1839091 "Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-1839107 "BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-186800 "PI3K catalyses the phosphorylation of PIP2 to PIP3"
Reactome:R-HSA-198266 "PI3K produces PIP3 and other phosphatidyl inositides"
Reactome:R-HSA-201510 "PI3K synthesizes PIP3 downstream of ALK"
Reactome:R-HSA-202365 "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3"
Reactome:R-HSA-2029271 "PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-2076220 "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3"
Reactome:R-HSA-2316434 "PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-2394007 "PI3K gain of function mutants phosphorylate PIP2 to PIP3"
Reactome:R-HSA-2424480 "PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-2730870 "Phosphorylation of PIP2 to PIP3 by PI3K"
Reactome:R-HSA-389158 "CD28 bound PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-392300 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3"
Reactome:R-HSA-437162 "PI3K alpha, beta, gamma convert PIP2 to PIP3"
Reactome:R-HSA-5218819 "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-5637801 "Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII"
Reactome:R-HSA-5654690 "FGFR1-associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-5654692 "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-5654697 "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-5654701 "FGFR2-associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-5654705 "FGFR3-associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-5654709 "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-5654714 "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-5654717 "FGFR4-associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-5655235 "Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-5655289 "Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-5655290 "Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-5655323 "Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-8852019 "MET bound PI3K generates PIP3"
Reactome:R-HSA-9021627 "EPOR-associated PI3K phosphorylates PIP2 to PIP3"
Reactome:R-HSA-9028519 "NTRK2-activated PI3K generates PIP3"
Reactome:R-HSA-9603445 "Activated NTRK3 stimulates PI3K activity"
Reactome:R-HSA-9664664 "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3"
Reactome:R-HSA-9664940 "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3"
Reactome:R-HSA-9665407 "PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3"
Reactome:R-HSA-9672162 "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers"
Reactome:R-HSA-9672177 "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR"
Reactome:R-HSA-9712084 "PI3K synthesizes PIP3 downstream of ALK mutants"
Reactome:R-HSA-9860816 "Phospho-PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 phosphorylates phosphoinositol-4,5-bisphosphate to yield phosphoinositol-3,4,5-trisphosphate"
RHEA:21292
RHEA:43396
RHEA:55632