FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

histone H3K9 deacetylase activity, NAD-dependent

ID (Ontology)

GO:0046969 (Gene Ontology)

Definition

Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + NAD+ + H2O = histone H3 L-lysine (position 9) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K9 to NAD, producing nicotinamide.[ PubMed:28450737 ]

Also Known As

"NAD-dependent H3-K9 histone deacetylase activity" ; "NAD-dependent histone deacetylase activity (H3-K9 specific)" ; "NAD-dependent histone H3K9 deacetylase activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
histone H3K9 deacetylase activity, NAD-dependent (all annotations which use CV term, excluding "NOT" statements)
enables \| histone H3K9 deacetylase activity, NAD-dependent

Spanning Tree (Parents/Children)

histone deacetylase activity
 |__histone deacetylase activity, NAD-dependent____
 |__histone H3K deacetylase activity_______________|
NAD-dependent protein lysine deacetylase activity  |
 |__histone deacetylase activity, NAD-dependent____|
                                                   histone H3K9 deacetylase activity, NAD-dependent  2 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	histone deacetylase activity, NAD-dependent histone H3K deacetylase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"NAD-dependent H3-K9 histone deacetylase activity" EXACT "NAD-dependent histone deacetylase activity (H3-K9 specific)" EXACT "NAD-dependent histone H3K9 deacetylase activity" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-9604829 "SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters"