FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term histone H3K27 methyltransferase activity ID (Ontology) GO:0046976 (Gene Ontology)
Definition Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein.
Also Known As"histone H3K27 methylase activity" ; "histone lysine N-methyltransferase activity (H3-K27 specific)" ; "histone methylase activity (H3-K27 specific)" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Gene Groups Genes
 histone H3K27 methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | histone H3K27 methyltransferase activity       --
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protein methyltransferase activity
 |__protein-lysine N-methyltransferase activity__
lysine N-methyltransferase activity              |
 |__protein-lysine N-methyltransferase activity__|
histone methyltransferase activity               |
 |__histone H3 methyltransferase activity________|
                                                 histone H3K27 methyltransferase activity  4 rec.
                                                  |__histone H3K27 dimethyltransferase activity 1 rec.
                                                  |__histone H3K27 monomethyltransferase activity 1 rec.
                                                  |__histone H3K27 trimethyltransferase activity 1 rec.
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Is a protein-lysine N-methyltransferase activity
histone H3 methyltransferase activity
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Synonyms
  • "histone H3K27 methylase activity" EXACT
    "histone lysine N-methyltransferase activity (H3-K27 specific)" EXACT
    "histone methylase activity (H3-K27 specific)" EXACT
    "histone methylase activity (H3-K56 specific)" EXACT
    "histone methyltransferase activity (H3-K27 specific)" EXACT
    "histone-H3K27 methyltransferase activity" EXACT
Secondary IDs
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Reactome:R-HSA-3240295 "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter"
Reactome:R-HSA-9764932 "PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter"
Reactome:R-HSA-9909631 "Trimethylation of CD274 gene promoter by EZH2"