FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term vitamin-K-epoxide reductase (warfarin-sensitive) activity ID (Ontology) GO:0047057 (Gene Ontology)
Definition Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 vitamin-K-epoxide reductase (warfarin-sensitive) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | vitamin-K-epoxide reductase (warfarin-sensitive) activity
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  oxidoreductase activity, acting on CH or CH2 groups
   |__oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
       |__vitamin-K-epoxide reductase (warfarin-sensitive) activity  1 rec.
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Is a oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
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Synonyms
  • "phylloquinone epoxide reductase activity" RELATED[ EC:1 ]
    "vitamin K1 epoxide reductase activity" NARROW[ EC:1 ]
Secondary IDs
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EC:1.17.4.4
MetaCyc:1.1.4.1-RXN
Reactome:R-HSA-159790 "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)"
Reactome:R-HSA-6806647 "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)"
RHEA:57744