FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
Help Close All Open All
General Information
Term phospholipid-hydroperoxide glutathione peroxidase activity ID (Ontology) GO:0047066 (Gene Ontology)
Definition Catalysis of the reaction: a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.[ PubMed:3978121 PubMed:8617728 ]
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 phospholipid-hydroperoxide glutathione peroxidase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | phospholipid-hydroperoxide glutathione peroxidase activity       2
Spanning Tree (Parents/Children)
Only view relationship: 
antioxidant activity_____________________________________
oxidoreductase activity, acting on peroxide as acceptor__|
                                                         peroxidase activity
                                                          |__phospholipid-hydroperoxide glutathione peroxidase activity  2 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a peroxidase activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "hydroperoxide glutathione peroxidase activity" RELATED
    "peroxidation-inhibiting protein activity" RELATED[ EC:1 ]
    "phospholipid hydroperoxide glutathione peroxidase activity" RELATED
Secondary IDs
hide External Crossreferences & Linkouts
EC:1.11.1.12
MetaCyc:1.11.1.12-RXN
Reactome:R-HSA-9018868 "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE"
Reactome:R-HSA-9018895 "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE"
Reactome:R-HSA-9020271 "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA"
Reactome:R-HSA-9020273 "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA"
RHEA:19057
RHEA:48620
RHEA:48888
RHEA:50708
RHEA:75835
RHEA:76687
RHEA:76691
RHEA:76695
RHEA:76699
RHEA:76703
RHEA:76707
RHEA:76711
RHEA:76715