FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term phospholipid-hydroperoxide glutathione peroxidase activity ID (Ontology) GO:0047066 (Gene Ontology)
Definition Catalysis of the reaction: a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.[ PubMed:3978121 PubMed:8617728 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 phospholipid-hydroperoxide glutathione peroxidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | phospholipid-hydroperoxide glutathione peroxidase activity
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antioxidant activity_____________________________________
oxidoreductase activity, acting on peroxide as acceptor__|
                                                         peroxidase activity
                                                          |__phospholipid-hydroperoxide glutathione peroxidase activity  2 rec.
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Is a peroxidase activity
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Synonyms
  • "hydroperoxide glutathione peroxidase activity" RELATED
    "peroxidation-inhibiting protein activity" RELATED[ EC:1 ]
    "phospholipid hydroperoxide glutathione peroxidase activity" RELATED
Secondary IDs
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EC:1.11.1.12
MetaCyc:1.11.1.12-RXN
Reactome:R-HSA-9018868 "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE"
Reactome:R-HSA-9018895 "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE"
Reactome:R-HSA-9020271 "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA"
Reactome:R-HSA-9020273 "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA"
RHEA:19057
RHEA:48620
RHEA:48888
RHEA:50708
RHEA:75835
RHEA:76687
RHEA:76691
RHEA:76695
RHEA:76699
RHEA:76703
RHEA:76707
RHEA:76711
RHEA:76715