FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

betaine-homocysteine S-methyltransferase activity

ID (Ontology)

GO:0047150 (Gene Ontology)

Definition

Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine.[ EC:2 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
betaine-homocysteine S-methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| betaine-homocysteine S-methyltransferase activity

Spanning Tree (Parents/Children)

  methyltransferase activity
   |__S-methyltransferase activity
       |__betaine-homocysteine S-methyltransferase activity  2 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	S-methyltransferase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"betaine-homocysteine methyltransferase activity" RELATED[ EC:2 ] "betaine-homocysteine transmethylase activity" RELATED[ EC:2 ] "trimethylammonioacetate:L-homocysteine S-methyltransferase activity" RELATED[ EC:2 ]
Secondary IDs

External Crossreferences & Linkouts
	EC:2.1.1.5 KEGG_REACTION:R02821 MetaCyc:2.1.1.5-RXN Reactome:R-HSA-1614654 "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY" RHEA:22336