FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term monoacylglycerol lipase activity ID (Ontology) GO:0047372 (Gene Ontology)
Definition Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+.
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       9
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 monoacylglycerol lipase activity (all annotations which use CV term, excluding "NOT" statements)       1      9
     enables | monoacylglycerol lipase activity       --       9
 NOT | enables | monoacylglycerol lipase activity       --       1
Spanning Tree (Parents/Children)
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hydrolase activity, acting on ester bonds
 |__lipase activity______________________
 |__carboxylic ester hydrolase activity__|
                                         monoacylglycerol lipase activity  10 rec.
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Is a lipase activity
carboxylic ester hydrolase activity
Part of
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Synonyms
  • "acylglycerol lipase activity" BROAD
    "fatty acyl monoester lipase activity" RELATED[ EC:3 ]
    "glycerol-ester acylhydrolase activity" RELATED[ EC:3 ]
    "monoacylglycerol hydrolase activity" RELATED[ EC:3 ]
    "monoacylglycerolipase activity" RELATED[ EC:3 ]
    "monoglyceridase activity" RELATED[ EC:3 ]
    "monoglyceride hydrolase activity" RELATED[ EC:3 ]
    "monoglyceride lipase activity" RELATED[ EC:3 ]
    "monoglyceridyllipase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.1.1.23
MetaCyc:RXN-19280
Reactome:R-HSA-1482543 "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL"
Reactome:R-HSA-163595 "2-acylglycerol + H2O -> glycerol + fatty acid"
Reactome:R-HSA-192422 "Digestion of triacylglycerols by extracellular PTL:colipase"
Reactome:R-HSA-192425 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)"
Reactome:R-HSA-192430 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)"
Reactome:R-HSA-192434 "Digestion of diacylglycerols by extracellular PTL:colipase"
Reactome:R-HSA-192475 "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2"
Reactome:R-HSA-426032 "DAG is metabolized by DAGL to 2-AG"
Reactome:R-HSA-426043 "2-AG hydrolysis to arachidonate by MAGL"
Reactome:R-HSA-5694462 "ABHD6,12 hydrolyse 3AG"
RHEA:15245
RHEA:32875
RHEA:34019
RHEA:38363
RHEA:38487
RHEA:38491
RHEA:39959
RHEA:40607
RHEA:44312
RHEA:44316
RHEA:44320
RHEA:44688
RHEA:44728
RHEA:47072
RHEA:58040
RHEA:58076
RHEA:58080
RHEA:58084
RHEA:58088
RHEA:58092
RHEA:58096
RHEA:58100
RHEA:78151