FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term ATP-dependent NAD(P)H-hydrate dehydratase activity ID (Ontology) GO:0047453 (Gene Ontology)
Definition Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + H+ + NAD(P)H + phosphate.[ EC:4 PubMed:3061454 ]
Also Known As "ATP-dependent H(4)NAD(P)OH dehydratase activity" ; "ATP-dependent H4NAD(P)OH dehydratase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 ATP-dependent NAD(P)H-hydrate dehydratase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | ATP-dependent NAD(P)H-hydrate dehydratase activity
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  carbon-oxygen lyase activity
   |__hydro-lyase activity
       |__ATP-dependent NAD(P)H-hydrate dehydratase activity  1 rec.
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Is a hydro-lyase activity
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Synonyms
  • "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing)" RELATED[ EC:4 ]
    "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)" RELATED[ EC:4 ]
    "ATP-dependent H(4)NAD(P)OH dehydratase activity" EXACT
    "ATP-dependent H4NAD(P)OH dehydratase activity" EXACT
    "reduced nicotinamide adenine dinucleotide hydrate dehydratase activity" BROAD[ EC:4 ]
Secondary IDs
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EC:4.2.1.93
KEGG_REACTION:R00129
MetaCyc:4.2.1.93-RXN
Reactome:R-HSA-6806967 "CARKD dehydrates S-NAD(P)HX to NADPH"
RHEA:19017
RHEA:32231