FB2026_03 , released September 17, 2026
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General Information
Term heparosan-N-sulfate-glucuronate 5-epimerase activity ID (Ontology) GO:0047464 (Gene Ontology)
Definition Catalysis of the reaction: (heparosan-N-sulfate)(n) = (heparan-N-sulfate)(n). Converts D-glucosyluronate residues to L-iduronate residues.[ EC:5 ]
Also Known As"heparosan-N-sulphate-glucuronate 5-epimerase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 heparosan-N-sulfate-glucuronate 5-epimerase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | heparosan-N-sulfate-glucuronate 5-epimerase activity
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  racemase and epimerase activity
   |__racemase and epimerase activity, acting on carbohydrates and derivatives
       |__heparosan-N-sulfate-glucuronate 5-epimerase activity  1 rec.
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Is a racemase and epimerase activity, acting on carbohydrates and derivatives
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Synonyms
  • "C-5 uronosyl epimerase activity" RELATED[ EC:5 ]
    "D-glucuronyl C-5 epimerase activity" RELATED[ EC:5 ]
    "heparosan epimerase activity" RELATED[ EC:5 ]
    "heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity" RELATED[ EC:5 ]
    "heparosan-N-sulphate-glucuronate 5-epimerase activity" EXACT
    "poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity" RELATED
    "polyglucuronate epimerase activity" RELATED[ EC:5 ]
Secondary IDs
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EC:5.1.3.17
MetaCyc:5.1.3.17-RXN
Reactome:R-HSA-2024100 "GLCE epimerises GlcA to IdoA"
Reactome:R-HSA-2076371 "GLCE epimerises more GlcA to IdoA as sulfate content rises"
RHEA:20197