FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term (S)-2-hydroxyglutarate dehydrogenase activity ID (Ontology) GO:0047545 (Gene Ontology)
Definition Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 (S)-2-hydroxyglutarate dehydrogenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | (S)-2-hydroxyglutarate dehydrogenase activity
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  oxidoreductase activity
   |__oxidoreductase activity, acting on CH-OH group of donors
       |__(S)-2-hydroxyglutarate dehydrogenase activity  2 rec.
           |__(S)-2-hydroxyglutarate dehydrogenase (quinone) activity 1 rec.
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Is a oxidoreductase activity, acting on CH-OH group of donors
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Synonyms
  • "(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase" RELATED[ EC:1 ]
    "(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase" RELATED[ EC:1 ]
    "2-hydroxyglutarate dehydrogenase activity" BROAD
    "alpha-hydroxyglutarate dehydrogenase (NAD+ specific)" NARROW[ EC:1 ]
    "alpha-hydroxyglutarate dehydrogenase activity" RELATED[ EC:1 ]
    "alpha-hydroxyglutarate oxidoreductase activity" RELATED[ EC:1 ]
    "hydroxyglutaric dehydrogenase activity" RELATED[ EC:1 ]
    "L-alpha-hydroxyglutarate dehydrogenase activity" RELATED[ EC:1 ]
    "L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase" NARROW[ EC:1 ]
Secondary IDs
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EC:1.1.99.2
MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN
Reactome:R-HSA-880050 "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2"
RHEA:21252
RHEA:30087
RHEA:57172